However, it as in the fourth round where a perfectly executed right hand, landing right above Crolla's ear, sent the challenger face first to the canvas.
"I thought it will be very hard for me, because his style is always in defense", said Lomachenko, still smiling despite a cut near his left eye from a fourth-round head butt.
Lomachenko continued to solidify his claim as the pound-for-pound best in the sport in a short career that has already saw him tie or set boxing records for the fewest fights to win a world title and the fewest to win titles in two and three divisions.
Lomachenko defended his WBA and WBO 135-pound belts with a violent fourth-round stoppage of Britain's Crolla on Friday night, demonstrating his pound-for-pound excellence with another virtuosic display.
"Lomachenko was too good for Anthony", he said.
Lomachenko believes he fractured his hand while delivering the final knockout punch and wanted the fight to be stopped earlier when he trapped Crolla on the ropes at the end of the third round.
Even when Lomachenko can't get an ideal opponent, he still puts on a show - and the raucous crowd of 10,101 at Staples Center enjoyed it.
"I want to unify all the titles", said Lomachenko, adding he wants to fight Mikey Garcia, who holds the WBC lightweight title.
Reiss ruled a knockdown late in Round 3 when combination punching from Lomachenko caused Crolla to sit down on the ropes while eating clean shots.
How can I watch Crolla vs Lomachenko?
The Ukrainian has developed a significant fan base in Los Angeles, where he lives and trains.
Lomachenko told Sky Sports: "Of course for me, more interest in Mikey Garcia, but if Mikey Garcia can't cut weight, maybe it will be Luke Campbell, maybe we can organise a fight in the UK". "That's my goal. I want historic fights".