She says that dealing with bullying on a daily basis inspired her to create her Be Best program, which aims to educate the public on the dangers of bullying on the internet.
The first lady sat down for the interview during her recent tour through Africa, where she was miles away from the politics of Washington, D.C. However, it seems that even when she's home, she chooses not to pay too much attention to what the media writes about her marriage - including Stormy Daniels's allegations of the president's infidelity.
Asked if she and the president still have a good marriage and if she still loves him, she replied, "Yes, we are fine".
"One of them - if you really see what people [are] saying about me".
Dressed in stretch jodhpurs with a pith helmet at her side - which drew criticism as a symbol of Europe's colonial occupation of the continent - Trump gave a wry smile when asked about comments about her marriage from the president's lawyer Rudy Giuliani.
Twitter users aren't feeling so sympathetic.
Trump has always been accused of infidelity, including a much-publicized liaison with porn actress Stormy Daniels.
"Media speculating, yeah, it's not always pleasant, of course", she said. She said she made known her distrust of some in the administration who no longer hold their positions, for example.
'It's what media speculate, and its gossip. "You need to ask him".
Llamas tried to get her to tell America if she has been hurt by her husband.
The full interview with Melania Trump will be broadcast on 20/20 tonight at 10pm EST.