Murkowski and Manchin were two of the final holdouts on how they would vote on Kavanaugh's confirmation, along with Republican Sens.
Democrats paraded to a almost empty Senate chamber overnight to lambast the nominee.
Supreme Court nominee Brett Kavanaugh's confirmation was roiled by allegations from several women that he had sexually assaulted him decades ago, when he was in high school or college with them.
Capping a venomous struggle that transfixed Americans when it veered into claims that Kavanaugh sexually assaulted women in the 1980s and his fierce denials, the 53-year-old conservative's nomination was on track for afternoon approval.
"If young boys behave well and with respect, they have nothing to worry about", Grossi said.
Earlier today, Senate lawmakers backed Kavanaugh by 51 to 49 in a procedural vote that moved the Republican-controlled Senate toward a definitive decision. And so I have been wrestling with whether or not this was about qualifications of a good man or is this bigger than the nomination.
Banks said Ford was "upset by it". "We must always remember that it is when passions are most inflamed that fairness is most in jeopardy".
Senator Collins ended hopes she would side with Democrats in the final vote, telling fellow senators she did not believe the "charges can fairly prevent Judge Kavanaugh from serving on the court".
A potential swing vote who had been regularly targeted by protesters in recent weeks, Flake's office was locked Friday and staff did not answer the door.
Manchin is in a tight race for re-election in his home state, where President Donald Trump beat Democrat Hillary Clinton by 42 percentage points in 2016.
"My heart goes out to anyone who has experienced any type of sexual assault in their life", Mr Manchin said.
Republicans control the Senate by a meager 51-49 margin.
Manchin was the only Democrat to vote for Kavanaugh's confirmation.
Murkowski sat solemnly during the roll call and whispered "No" when it was her turn to vote. Instead, "It's turned our base on fire", Senate Majority Leader Mitch McConnell, R-Ky., told reporters. Susan Collins (R-ME) who will announce how she is voting at 3:00 pm Friday. "What she did was to come forward and testify before the Senate Judiciary Committee and agree to cooperate with any investigation by the FBI and that's what she sought to do here", Katz said.
Demonstrators protest the appointment of Supreme Court nominee Brett Kavanaugh in Washington DC, on October 6, 2018. "And that is hard".
Kavanaugh's confirmation hinges on the votes of some other key moderate senators including Sen. Steve Daines, who supports the nominee but will be at his daughter's wedding in Montana. Murkowski said she'd use an obscure procedure that lets one senator offset the absence of another without affecting the outcome.
For Kavanaugh to be defeated, two senators who voted to end debate on his nomination, effectively allowing it to proceed, would ultimately have to vote against him.
On Friday, Sen. Jeff Flake, the Republican who stalled Kavanaugh's nomination process by wielding his leverage to call for the Federal Bureau of Investigation review, announced he would vote for Kavanaugh unless something major changes before Saturday.
Vice-President Mike Pence planned to be available Saturday in case his tie-breaking vote was needed, which now seems unlikely.