Raphael Gurrero whipped in a cross from a short corner and as the ball crossed Ronaldo's head, Pepe jumped high to meet the cross and fetch the equaliser for his side 10 minutes into the second half. His second goal was all about technique as he used his right foot to curl the ball beyond the fingertips of Rui Patricio to muzzle Portugal.
He was an ever present thorn in Portugal's backline with his height, physicality and technical ability allowing him to pose a threat in a number of different ways, creating a handful for the opposition to deal with. It was Cavani who launched the attack, switching play to the other flank where his ball found a charging Suarez.
Even before the tournament began, Suarez and Cavani stood out as one of the World Cup's deadliest duos; they scored a combined 71 goals last season for Barcelona and Paris Saint-Germain, respectively.
"We must congratulate Uruguay because they are the national team that are in the quarter-finals", he said post-match. But he also admitted it'll be a group effort trying to slow down Portugal's star.
Ronaldo will be 37 when the Qatar World Cup comes around - although you certainly wouldn't bet against him making himself available for that.
Meanwhile, Ronaldo did not touch the ball once in the opposition area in the first period.
In fact, three statistics show just how bad Ronaldo was during his side's loss to Uruguay.
Cristiano congratulated Uruguay, FIFA and Russian Federation for the hosting of the World Cup, while refusing to make a fuss about his future with the national team. Suarez is an unselfish team player who will run channels from minute one to 90.
The back four deserve just as much credit as the front two do, as Pepe's goal was the first time La Celeste's defence has been breached since the turn of the year.