City will be crowned the Premier League champion on Monday (AEST) in the unlikely event of rock-bottom West Bromwich Albion beating Manchester United, but glory will come regardless if it beat Swansea City next weekend.
A tumultuous return from the global break for Manchester City has come to an end.
Gabriel Jesus raced in behind an unsettled Spurs defence to drill home the opener on 22 minutes and Ilkay Gundogan slotted home the second from the penalty spot three minutes later as Hugo Lloris wiped out Raheem Sterling, although replays suggested the contact took place outside the area.
Yet City had three good chances to restore their two goal lead, the two of those fell to Jesus who was twice put through but on each occasion got the ball caught up in his feet and the chances went begging.
Spurs include their own Sterling...
Of course, that result only delays their inevitable march to the Premier League title, but it was a remarkable collapse.
The otherwise anonymous Harry Kane played a perfectly weighted pass through to Christian Eriksen in the box, who scored in the most fortuitous of circumstances, as his shot hit Aymeric Laporte and rebounded back off the Spurs man into the net.
While City have an embarrassment of riches from which to piece together a starting XI, they are without a number of key figures at present.
Prior to this evening, Spurs hadn't lost a Premier League home game by a margin of two or more goals since August 2014 (0-3 v Liverpool).
Steve Wilson: "Let's get this straight, Manchester City have been fantastic this season - unbelievable".
Meanwhile, Spurs may be looking nervously over their shoulder, as fifth-placed Chelsea are now seven points behind them with five matches left to play.
Champions League semi-finalists Liverpool welcome Bournemouth to Anfield at 5.30pm while in the game of the day Tottenham Hotspur host Manchester City at a quarter to 8. After a handful of missed opportunities at Wembley, question marks over his finishing undoubtedly remain, but the England international's character was the latest attribute to show signs of improvement as finally took his chance to propel City to the brink of the title.
The team news was posted on the official Tottenham Twitter page ahead of the 7.45pm kick-off.