The Tottenham hot shot has been out injured since March 11 with damaged ankle ligaments.
"If not this weekend maybe next weekend, but the most important is that we are so positive about his recovery, he is doing fantastic". I think, when you play this type of game, I think the pressure is for both teams. I can not give opinions about a context that I wasn't there [for]. He is doing fantastic.
"After Bournemouth everybody believed it would be a long period out, but the resolution has been fantastic", Pochettino added.
"I think it always a massive game because it's a London derby", said Pochettino.
However, speaking at a press conference on Thursday afternoon, Pochettino appeared to indicate there was some chance Kane could be involved. Fourth-placed Tottenham now occupy the final qualification spot and sit five points ahead of Chelsea with eight games left this season.
The two sides face each other at Stamford Bridge, with both teams looking to secure a top-four finish to ensure participation in next season's UEFA Champions League. "But for us three points would put us in a very good position in the table".
"It will be a very tough game and they are always a tough team to compete with". This is not a decisive game, but always it is important for your confidence, your motivation.
Pochettino suggested that if Kane, who has scored 31 goals in all competitions, can not return against Chelsea, he may be ready to face Stoke City on April 7.
"I think it is not a point of focus for us".