Officials believe Rodriguez and Frisina may be headed northeast to NY or Canada, ABC News reported.
There are no pending criminal charges against Rodriquez, but if located, Caitlyn would be returned to her parents custody in Columbia County.
A friend told investigators that Caitlyn sent her a text indicating she may have a relationship with the coach.
"If you see this, pumpkin, we just want you to know that we love you and we miss you, and we need to know that you're safe", Scarlet Frisina said at a Wednesday news conference at the Columbia County Sheriff's Office.
A 17 year old girl and a high school soccer coach from Columbia County were last spotted in North Carolina Sunday, police announced Thursday.
Authorities are concerned for Frisina's safety because she is a minor and because there is a 10-year age gap between her and Rodriguez.
Rodriguez is thought to be driving a red Mercury Sable.
"A Fla. MISSING CHILD Alert issued for Caitlyn Frisina, W/F, 17yo, 5'7", 135lbs, BR hair & eyes, from Lake City. "Caitlyn has a current boyfriend who also is beside himself because everything was fine", Smith said. "We need to know that you're OK".
Data on a teenager's phone was completely erased before she went missing.
Rodriguez was a high school boys' soccer coach at Fort White High School, but he has been suspended pending the investigation, according to a statement from Lex Carswell, superintendent of Columbia County Schools. I will come to you no matter the time or place! She left with only a few clothes. "Help us get in contact with her anyway possible!" No other comments will be made pending this investigation. This is a picture of me and Caitlyn Morgan Frisina my...
Authorities found that Frisina took out $200 at a Pilot Travel Center on St. Mary's Road in St. Mary's, Georgia.
Anyone with information should call 911 or contact Detective D. Marszalek at 386-719-2005.