The Cowboys (7-1, 3-1 Big 12) remained in the thick of the conference race by beating the Mountaineers (5-3, 2-2) for the third straight season.
West Virginia turned it right back to the Cowboys on the next play, as Will Grier was intercepted by Ramon Richards, who returned it to the 50. Hill finished with 86 yards on 12 carries with the two touchdowns.
His counterpart Rudolph completed 20 of 34 passes for a season-low 216 yards but mixed in two scoring throws to James Washington and another to King, whose 41 touches in relief helped OSU keep humming.
A poor hold by Zach Sinor caused a missed extra point by Matt Ammendola and it was 13-0 Cowboys with 1:02 to play in the first quarter.
West Virginia will start off with a neutral site game against struggling Tennessee, and go on the road to face a strong NC State team to round out the pre-conference schedule. King also caught five passes for 29 yards and a touchdown.
West Virginia pulled within 30-24 in the third-quarter, finding momentum not from its offense but on a blocked punt recovery by Marvin Gross and pick-six by Kenny Robinson.
Oklahoma State has made a living lighting up scoreboards under Mike Gundy and putting up staggering passing numbers, but Glenn Spencer's defense is a big reason this might be one of Gundy's most balanced teams.
The Cowboys forced five turnovers, including four interceptions. With his touchdown pass to J.D. King in the third quarter, Rudolph passed Brandon Weeden's record of 75 career touchdown passes. Washington finished with 91 yards on seven catches for 91 yards.