The bus was transporting inmates from Hancock State Prison in Hancock County to the Georgia Diagnostic and Classification Prison in Eatonton, about 45 miles away.
Law enforcement went door-to-door Tuesday morning informing people about what happened and urging them to lock their doors as the search continues.
A $60,000 reward is being offered by law enforcement authorities for information that leads to the arrests of two #Georgia escapee-inmates, Ricky Dubose and #Donnie Russell Rowe.
The Putnam County Sheriff's office confirmed to 11Alive in Atlanta that two prisoners being transported were able to overpower the guards on the bus before killing them and escaping.
They're risky. Call 911, don't approach them, ' Sills said Bus was carrying 33 prisoners going to various locations from the Hancock State Prison [READ: Departments send condolences after correctional officers killed] In July 2016, Monica accepted a job at the Transportation Unit in Milledgeville, Georgia.
Sills described the fugitives as violent repeat offenders and extremely risky, having taken the guards' 9 mm pistols.
Sills said Ricky Dubose and Donnie Rowe broke into a house off US 441 in Morgan County and left their prison clothes behind at about 10:30 - 11 a.m. Tuesday.
"I saw two brutally murdered corrections officers, that's what I saw", he said.
The Oconee County Sheriff's Office, north of where the officers were killed, published a Facebook post encouraging the men to turn themselves in.
It is standard protocol to have two officers - armed but not wearing ballistic vests - transport prisoners on a bus, authorities said.
CORRECTS SOURCE TO GEORGIA DEPARTMENT OF CORRECTIONS IN SIGNOFF- This undated photo released by the Georgia Department of Corrections Tuesday, June 13, 2017, shows inmate Ricky Dubose.
Two correctional officers were shot and killed by an inmate who escaped in Putnam County. Billue, a 10-year employee, is survived by a father, a brother and a sister, Dozier said. His biggest fear, he said, is that they're going to kill someone else. "Their blood on my shoes", said Sheriff Howard Sills.
The pair allegedly broke into a home in the city of Madison later, stole clothes and food, and later entered a nearby Family Dollar store, the Atlanta Journal-Constitution reported Wednesday.
"We lost two of our fellow officers, two of our kin".
Corrections Commissioner Greg Dozier told The Associated Press that inmates don't know their transfer date ahead of time.
The US Marshals Southeast Regional Fugitive Task Force and the Georgia Bureau of Investigation are involved along with several other agencies.
Rowe, whose nickname is "Whiskey", was convicted of armed robbery and is in prison for life without parole.
A photo released by the sheriff's office in Elbert County, the site of his most recent conviction, shows Dubose with prominent tattoos.
"They were inside the caged area of the bus", Sills said. He also has a tattoo featuring large letters covering the entirety of the front of his neck.