This was Perry's second time dedicating her "Part of Me" track to the Manchester victims, as she also performed the song at an intimate venue in London just days after the tragedy.
Ariana Grande made her fearless return to Manchester over the weekend following last month's bombings outside of her concert that left 22 dead and dozens injured.
A petition urging Manchester Council to give Ariana Grande "Freedom of the City of Manchester" has gained momentum online since last night's concert. The fund "will help alleviate immediate suffering and ensure victims and their families do not face short-term financial difficulties", the British Red Cross tweeted.
In addition to organizing the event, Grande re-released her 2015 single "One Last Time", and all the proceeds will go to the We Love Manchester Emergency Fund. The remainder of the tickets for the show at the Emirates Old Trafford Cricket Ground-which has a capacity of about 50,000-sold out in under six minutes.
Although there were many big names on stage, Grande was the one who made the most compelling presence of the night.
Other performers included Black Eyed Peas, Justin Bieber, Katy Perry, Take That, Robbie Williams, Coldplay and a special performances by former frontman of Manchester band Oasis, Liam Gallagher. She visited the victims of the attack and promised huge support, saying that compassion, kindness, love, strength is the right answer to what happened on May 22.