The local Rheinsche Post website reported a "large-scale operation" on behalf of police.
A reporter for German newspaper Der Speigel at the scene said he had seen two injured people, and the situation was returning to calm.
In October, police say they prevented an attack on a Berlin airport by a Syrian refugee, 22-year-old Jaber al-Bakr.
"I helped her wound and called her father", she said.
A passenger on a Dusseldorf bound train, Bruno Macedo, tweeted: "Breaking: Man with axe chased by police in Dusseldorf. Station closed. I am in the train things look bad #police #terror".
Outside the main railway station in Dusseldorf.
Staff members are pictured inside Dusseldorf train station March 9, 2017 after a man attacked several people at the train station.
Heavily-armed special police forces swooped in on the station, located in the center of Germany's ninth-largest city.
Police confirmed there was an "extensive" operation at the station following reports of "injuries".