New England gained 402 yards on the Los Angeles defense, which was an improvement over what the New Orleans Saints did to the Rams in the previous game.
This loss will drop the Rams to 4-8 while the Patriots ascend to 10-2.
Tom Brady now stands alone when it comes to career victories by an National Football League quarterback.
There may be room for debate in some circles as to whether Tom Brady is the greatest quarterback to ever play the game, but following the New England Patriots' 26-10 dismissal of the dismal Los Angeles Rams on Sunday, there is no question as to the winningest passer in history.
Brady, who was 33 of 46, had tied Peyton Manning (pictured in January), who has 200 wins, last week in a win over the New York Jets.
Brady wasn't entirely thrilled with the results - "There were a lot of plays I thought we left out there", he said - but knows this offense will adjust. And he said later he was "very grateful" for his teammates, coaches, family and friends. He now has 19 touchdowns and one interception and is on pace to best his 36-touchdown, four-interception ratio from the 2010 season.
Brady, who threw one touchdown pass, also picked up his 179th regular-season win, leaving him one shy of Manning and Brett Favre (186 each) as the only quarterbacks with 180 victories. The Rams rank 29th or worse in yards per game and per play, rushing yards per game and per play, passing yards per game, third down efficiency and points per game. "Right now, we've got to make sure we stay on our P's and Q's, and cross our X's and just continue to do what we've got to do to make sure that we continue to win these games". After all, when it came to playing games against Rams coach Jeff Fisher, 58, the Patriots have outscored him 104-7.
Asked a similar question during his weekly appearance on WEEI, Brady said: "We're playing for a lot here".
"I kind of made a point to watch his first drive". "I think we've still got a lot of other players who can fight as well". Including Miami's final two drives, the Rams have yielded nearly 20 percent of all the yards passing they've allowed in the entire season over the past 4 1/2 quarters. Niners quarterback Colin Kaepernick was sacked five times and completed just one pass for four yards was benched in the fourth quarter in favor of Blaine Gabbert, but that didn't stop San Francisco from falling to an 11th straight defeat. It appears to be proof that New England feels it has the personnel to keep defenses guessing.
A group of New England Patriots defenders tackle Los Angeles Rams tight end Lance Kendricks (88) dur ... The interception by Malcolm Butler led to another Patriots' touchdown.
Baltimore Ravens quarterback Joe Flacco had a big day, throwing for 381 yards and four touchdowns in a 38-6 blowout win over Miami. Blount gained more yards than that on his touchdown run.
Rams starting cornerback E.J. Gaines suffered a quadriceps injury in the second quarter and did not return.
He was later spotted walking on crutches in the tunnel underneath Gillette Stadium.