Several players worked directly with Nike, Under Armour and adidas to design their custom kicks to wear during game action in Week 13.
The My Cause, My Cleats campaign runs this week and players have gone above and beyond to ride out for their cause.
"My Cause, My Cleats" offers players the rare chance at individuality with their gameday uniform. The player cleats will be worn during Week 13 games and some players will use their cleats to raise awareness for their respective causes.
The Cowboys and Vikings play Thursday night so those will be the first cleats you see this week.
Dallas running back Ezekiel Elliott is wearing cleats with puppy prints and dog bones on them to spread of word of preventing animal cruelty. If you wear the wrong cleats without National Football League permission, or carry on too much celebrating a touchdown, you might get a large fine.
"One of the great NFL traditions is how our players passionately support important causes in their communities and around the globe every year", said NFL Commissioner Roger Goodell said in a statement.
Players are sharing the stories behind their cleats on The Players' Tribune and on social media using the hashtag #MyCauseMyCleats.
Kirk Cousins will wear cleats to support anti-human trafficking causes.